![]() ![]() ![]() The district is also known as a destination for Indo-Chinese cuisine. Establishments have appeared on food critics' "best of South Asian cuisine" national and regional lists. Over 145 Indian restaurants alone are found in the neighborhood. Indian-American supermarket chain Patel Brothers has a location on the strip. Many come to the area for its traditional gold and Maharashtrian jewelry retailers. Oak Tree Road in Edison and Iselin is home to over 400 South Asian business establishments, including dining, halal grocery, jewelry, apparel and electronics retailing, and entertainment. Culture, cuisine, and commerce Saravana Bhavan restaurant off Oak Tree Road in Edison According to the 2017 American Community Survey, 42.6% of Iselin residents identified themselves as being Asian Indian, the highest for any census-designated place in the United States. This area is the largest and most diverse South Asian ethnic enclave and cultural hub in the United States. county with the highest concentration of Indian Americans. Middlesex, in Central Jersey, is the U.S. Some have lamented the " stroad" status of parts of the western portion of the strip as inhibiting ideal walkability from establishment to establishment, and have advocated for improved sidewalks. The intersection of Wood Avenue and Oak Tree Road is where the two towns meet. The epicenter of Little India retail is traditionally on the two-block stretch of Oak Tree Road between Correja Avenue and Middlesex Avenue in Iselin, an area officially known as India Square there, as of 2017, rents were roughly double over the rest of the strip. Oak Tree Road runs for about one-and-a-half miles through Edison and neighboring Iselin, a section of Woodbridge Township. The district, which has been called "Little India," is set amidst a suburban residential area that is home to many South Asian families. Oak Tree Road is a predominantly South Asian shopping, business, and dining district centered on a road designated County Route 604 in Middlesex County, in Central New Jersey. The current clinical interventions in malignant melanomas are met with poor response to therapy due to dynamic regulation of multiple melanoma signaling pathways consequent to administration of single target agents.South Asian shopping district in Edison, New Jersey. ![]() In this context of limited response to single target agents, novel candidate molecules capable of effectively inducing tumor inhibition along with targeting multiple critical nodes of melanoma signaling assume translational significance. In this regard, we investigated the anti-cancer effects of a novel dichlorophenyl urea compound called COH-SR4 in melanoma. The SR4 treatment decreased the survival and inhibited the clonogenic potential of melanomas along with inducing apoptosis in vitro cultures. SR4 treatments lead to inhibition of GST activity along with causing G2/M phase cell cycle arrest. ![]() Oral administration of 4mg/kg SR4 leads to effective inhibition of tumor burdens in both syngeneic and nude mouse models of melanoma. The SR4 treatment was well tolerated and no overt toxicity was observed. The histopathological examination of resected tumor sections revealed decreased blood vessels, decrease in the levels of angiogenesis marker, CD31, and proliferation marker, Ki67, along with an increase in pAMPK levels. Western blot analyses of resected tumor lysates revealed increased PARP cleavage, Bim, pAMPK along with decreased pAkt, vimentin, fibronectin, CDK4 and cyclin B1. Thus, SR4 represents a novel candidate for the further development of mono and combinatorial therapies to effectively target aggressive and therapeutically refractory melanomas. Melanoma arises from the malignant transformation of the pigmented cells of the skin called melanocytes. The incidence of cutaneous melanoma has been rising in the past decade. ![]()
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